Studies on danofloxacin in chicks vaccinated with newcastle disease virus vaccine

ABSTRACT

In Hubbard chicks, oral administration of therapeutic and twofold dose of danofloxacin for three successive days post-vaccination with Newcastle disease virus vaccine induced a slight immunostimulant effect manifested by an increase in haemagglutination inhibition titres in vaccinated treated groups. Moreover, the drug at therapeutic doses, resulted in a significant [P < 0.05] increase of body gain in treated chicks compared with non treated ones. On the other hand, therapeutic doses of danofloxacin had no adverse effects on liver and kidney functions. Double therapeutic doses of danofloxacin elicited a significant [P < 0,05] increase in serum uric acid, creatinine, urea, alkaline phosphatase, aspartate amino transferase and a decrease in serum albumin. In addition, degenerative changes in liver and kidney, and lymphocytic depletion in the thymus, spleen and bursa of fabricius were detected. It could be concluded that therapeutic doses of danofloxacin Induce a slight immunostimulant effect in chicks immunized with Newcastle disease virus vaccine, coupled with no adverse effects on body gain, liver Nrand kidney functions