[Disposition of sulfonamides in food-producing animals: pharmacokinetics of sulfamethoxazole in goat]

ABSTRACT

Sulfonamides with or without diaminopyrimidine derivatives [DAP] such as trimethoprim, baquiloprim and aditoprim are among the most widely used chemotherapeutic agents in veterinary medicine. They are being used for the treatment of various systemic bacterial infections in ruminants. Inspite of sulfonamides are widely used with or without the new products of DAP derivatives in animals but for most of them adequate pharmacokinetic information is scarce. Thus the present study was carried out on the pharmacokinetic aspects of sulfamethoxazole in goats. The drug was given at a 2 week interval by intravenous [i.v.] or intraruminal route at a dose of 30 mg/kg body weight. After i.v. injection the mean half life value was 1.04 hour, mean distribution value was 0.22 1/kg and mean clearance value was 0.14 1/kg/hour. After oral administration the bioavavilability value was low. Elimination half life value was significantly prolonged probably due to a slow rate of drug absorption from the gastro intestinal tract