Assessment of fibrinolytic system in uremic patients under regular haemodialysis treatment

ABSTRACT

In order to clarify, the status of fibrinolytic system in patients with chronic renal failure undergoing regular haemodialysis, palsmingen [PLG], tissue plasminogen activator [tPA], alpha [1]. Antitrypsin [alpha [1]-AT], alpha Antiplasmin [alpha [2], AP] and Plasmingen activator inhibitor -I [PAI] had been estimated immediately before and after haemodialysis in 20 patients with primary chronic renal failure on regular haemodialysis undergoing 4-5 hours of regular haemodialysis treatment [RDT] [3] times a week. Duration of haemodialysis [HD] was 8-99 months. These values were compared with those obtained from 20 matched healthy control subjects. PLG, alpha [2] AP and PAI values decreased in CRF patients under RDT than normal control values, while no significant differences had been found before and after dialysis. No significant differences had been found between control group and CRF patients under RDT in case of tPA and alpha [1], AT. Also no difference had been found before and after dialysis in case of alpha [1] AT. However, a highly significant increase had been found between before and after dialysis in case of tPA. So, increased fibrinolytic activity druing HD is probably chiefly due to the effect of extracoporal circulation using the artificial kidney with the release of tPA from vessel walls and consequent consumption of PAI-l. It is probable that plasminogen activator is a feature of many, if not all, forms of extracorporal circulation