randomized trial of brief treatment of early-stage Hodgkin lymphoma: is it effective?

ABSTRACT

Whether it is possible to reduce the intensity of treatment in early [stage I or II] Hodgkin lymphoma with a favorable prognosis remains unclear. Therefore, we conducted this random-ized trial, comparing two treatment groups consisting of a combination chemotherapy regimen of two different intensities followed by involved-field radiation therapy at two different dose levels. Prospective, randomized, in patients referred to the Department of Clinical Oncology and Nuclear Medicine. Ninety-eight patients with histologically proven early-stage Hodgkin lymphoma with a favorable prognosis were enrolled in this study between January 2008 and June 2010. They were randomly assigned in one of two treatment arms arm I received four cycles of ABVD [Adriamycin, belomycin, vinblastine, dacarbazine]] followed by 30 Gy of involved-field radiation therapy; arm II received two cycles of ABVD followed by 20 Gy of involved-field radiation therapy. During the follow-up period, the 2-year relapse free survival rates were 96% and 95% in arm I and arm II, respectively [P=.8], while the 2-year overall survival rates were 98% and 95% in arm I and arm II, respectively [P=.16]. Acute toxicity affected 54% of patients treated with four cycles of ABVD, who had grade III or IV toxicity, as compared with 30% of those receiving two cycles [P<.02]. The rates of acute toxicity [grade III or IV] were also higher among patients treated with 30 Gy of involved-field radiation therapy than among those receiving 20 Gy [16% vs. 2.5%, P<.03]. In patients with early-stage Hodgkin lymphoma and a favorable prognosis, treatment with two cycles of ABVD followed by 20 Gy of involved-field radiation therapy was as effective as, and less toxic than, four cycles of ABVD followed by 30 Gy of involved-field radiation therapy