Evaluation of paclitaxel and carboplatin versus combination chemotherapy with fluorouracil doxorubicin and cyclophosphamide as a neoadjuvant therapy in patients with inoperable breast cancer

ABSTRACT

To compare the results of patients with locally advanced breast cancer receiving two different regimens Fluorouracil, Doxorubicin and Cyclophosphamide [FAC] and Paclitaxel and Carboplatin. Comparative study. The Oncology Department, Institute of Nuclear Medicine and Oncology [INMOL], Lahore, from March 2007 to September 2008. Patients with inoperable locally advanced breast cancer of stage were included. Sixteen patients were given FAC regimen and 9 patients were given Paclitaxel and Carboplatin, each combination was cycled after 21 days for four times. Before enrollment, detailed medical histories, physical examinations and performance status assessments were done as well as postchemotherapy evaluation with regular follow-up visits was done. Complete Response [CR, xLlOO%] is defined as the disappearance of all known disease parameter i.e. disappearance in detectable tumour size, node free disease and surgery is possible. Paratial Response [PR, "L > 50%] was defined by 50% or greater decrease in the sum of the areas of bidimensionally measured lesions i.e. change of N2 to N1 or no status and some surgical procedure is possible to downstage the disease. Minor Response [MR] was defined as a decrease in the tumour insuffieceint to quality for partial responce. Static disease or no evaluable reflected no significant change in disease and no evidence of new disease. Progression of disease [> 25%] was defined as a 25% or greater increase in the area of any lesion > 2 cm or in the sum of the products of the individual lesions or the apprearance of new malignant lesions, surgery not possible. Twenty five patients completed neoadjuvant chemotherapy. Sixteen [66%] patients received FAC and 9 [37%] patients received PC chemotherapy. Overall CR [breast and axilla] was 54%, PR was 16% and minor response [MR] was 8%. FAC treatment induced more emesis, mucositis, alopecia and cardiotoxicity. No death occurred. The Paclitaxel and Carboplatin regimen was better tolerated; both regimens were effective in improving disease and overall survival