[Antibacterial activity of 7 species of medicinal plants on bacteria isolated from UTI patients in golestan province]

ABSTRACT

Urinary tract infection [UTI] is extremely prevalent in the world. Despite treatment with antibiotics, recurrency is common in the patients and there is potential for developing antibiotic resistance. The aim of this study was to investigate the antibacterial activity of ethanolic extracts of 7 medicinal plants on pathogenic bacteria causing Urinary Tract Infection. Plants were collected from their natural habitats in Golestan province [North of Iran]. Antibacterial effects of ethanolic extracts were analyzed by disc diffusion method. Also the Minimum inhibitory concentration [MIC] of the extracts was determined by the microdilution Broth. The results showed that Berberis vulgaris was the most effective extract with 29.4 mm diameter of inhibition zone on gram positive bacteria specially S. epidermidis. A. calcoaceticus, S. aereus, S. epidermidis, and S. saprophyticus were the most sensitive bacteria with maximum inhibition zone of 20.1, 26, 29.4, 28.5 mm, respectively. P. aeroginosa, C. freundii, K. pneumonia, and P. mirabilis were the most resistant bacteria in this research. Also extracts had better antibacterial effect in amount of 100 mg/ml. The lowest MIC values was measured in Berberis vulgaris with 0.09 mg/m10 against S. epidermidis. Gram positive bacteria were more sensitive than gram negative bacteria. These plants in native's traditional medicine have been used by rural people as antiseptic for the treatment of UTI. In addition, Our results showed that Berberis vulgaris and Hypericum perforatom were have strong antibacterial effects. In addition to Traditional uses of these plants in Golestan province for the treatment of UTI symptoms, invitro evaluation and clinical trials for their effects to treat UTI is suggested for future research