Serum uric acid as predictor model for pre eclampsia

ABSTRACT

To determine that serum uric acid as a predictor in pre-eclampsia during pregnancy. To determine fetal and maternal outcome in pregnancy with hypertension. Case control study. Gyne Unit-2, Civil Hospital Karachi. Duration 8 months [1st March 2008 to 30 October 2008]. 30-Cases of singleton primigravida with BP > 160/110 mmHg and 30-Cases of singleton primigravida with Normal BP 120/80 mmHg were studied at the time of delivery. Thirty Patients with pre-eclampsia taken along with thirty patients with normal BP, since higher proportion of un-booked woman in Pre-eclampsia group than normotensive group. Significantly low gestational age in Pre-eclampsia group mean is 34 weeks and 37 weeks for normotensive group. Mean age of marriage for both groups is 1-2 years in both groups. No difference in mean age in pre-eclampsia and normotensive group that may be due to duration of marriage and early marriage trend in our culture. History of hypertension is seen in 19 [63.3%] of patients. The average birth weight of patients with pre-eclampsia is 2.5 Kg and 3 Kg for normotensive group. Difference may be due to preterm delivery in pre-eclampsia. Apgar score low in pre-eclampsia group. Increase caesarean rate is 93.3% Vs 20% in pre-eclampsia and normotensive group. This difference is due to the fact the caesarean section is considered to be safest mode of delivery for pre-eclampsia group. Uric acid level > 0.45 mmol/1 was observed in 15 patients [50% of pre-eclampsia group] and 7 patients [23.3% of woman with normal blood pressure]. Maternal hyper uricemia is a strong predictor of maternal disease progression and fetal outcome. Thus it can be used as useful and inexpensive marker of predicting pre-eclampsia and fetal growth retardation in women presenting with gestational hypertension