T-cell protein tyrosine phosphatase: a role in inflammation and autoimmunity
International Journal of Diabetes Mellitus. 2010; 2 (2): 114-118
in English
| IMEMR
| ID: emr-117853
ABSTRACT
A cDNA of PTPN2 encoding for T-cell protein tyrosine phosphate [TC-PTP] was isolated and characterized as long as 20 years ago. However, findings suggesting a potentially exciting role of this enzyme in general autoimmunity have only recently been obtained. Genome-wide association scans of the human genome revealed the involvement of PTPN2 in susceptibility to a several autoimmune disorders such as Crohn's disease, type 1 diabetes, and Graves' disease. Functional studies in immune cells revealed a key role of this enzyme in down-regulation of cytokine expression and inflammatory response, which provides an essential background to explaining the pathophysiological role of TC-PTP in autoimmunity. Thus, in addition to PTPN22, PTPN2 is likely to represent a second member of the broad family of non-receptor PTPs contributing to general autoimmunity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Autoimmunity
/
Genome
/
Protein Tyrosine Phosphatase, Non-Receptor Type 22
/
Inflammation
Limits:
Humans
Language:
English
Journal:
Int. J. Diabetes Mellitus
Year:
2010
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