JPAD-Journal of Pakistan Association of Dermatologists. 2011; 21 (4): 265-269
in English
| IMEMR
| ID: emr-118211
ABSTRACT
Melasma is a common acquired macular hyperpigmentation which involves mostly the sun exposed areas of face and neck. To assess the efficacy of the combination of 20% azelaic acid with 0.05% tretinoin cream in the treatment of melasma. 30 patients of melasma were treated with daily night application of 20% azelaic acid and 0.05% tretinoin. Patients were assessed at 4, 8 and 12 weeks of treatment using melasma area severity index. Side effects during therapy were also noted. Majority i.e. 43% cases were between 26 to 30 years, 73.3% of patients were females and 56.7% were housewives, 70% were married and 86.7% were in middle class. Family history of melasma was positive in 66.7% cases. 93.3% patients had no history of systemic drug and 73.3% had no history of use of cosmetics. 93.3% of patients had malar area involvement and 6.7% had centrofacial area involvement. After treatment, the average MASI score decreased by 38.66% indicating moderate reduction of the severity of melasma. Burning sensation, itching and erythema developed in 50%, 30% and 16%, respectively. The combination of 20% azelaic acid and 0.05% tretinoin cream in the treatment of melasma has a moderate lightening effect with some remarkable side effects
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Tretinoin
/
Treatment Outcome
/
Dicarboxylic Acids
/
Drug Therapy, Combination
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
J. Pak. Assoc. Dermatol.
Year:
2011
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