Modulation of ulcerogenicity of Ibuprofen and Indomethacin via blocking the H[2] receptors in the stomach

ABSTRACT

Among the commonest side effects of NSAIDs are the gastrointestinal manifestations, which could reach gastric erosions, ulcerations, or recurrent liberations in people using NSAID for long durations. This provided idea of accomplishing this work in order to study the possibility of avoiding these side effects, which stand as a strong barrier against the regular use of these drugs. This study aimed at finding a way out from these serious side effects such as gastric ulcers, so that a member of the H[2] receptor antagonists; namely ranitidine, was thought to accompany the treatment with indomethacin being the classic example of the NSAIDs, and ibuprofen; which is one of the most commonly used NSAIDs. The ulcer index was the measure to reach a fair judgment comparing the use and the non-use of ranitidine with indomethacin and ibuprofen therapies. Results were much better when ranitidine was taken as an adjuvant treatment to indomethacin and ibuprofen, a situation indicating the necessity of considering prescribing one of the H[2] receptor antagonists with the NSAIDs therapy, especially in prolonged use