Experimental schistosomal hepatitis: protective effect of coenzyme-Q10 against the state of oxidative stress

ABSTRACT

Schistosoma mansoni [S. mansoni] eggs trapped in the host liver elicit a chain of oxidative processes, where they not only trigger the production of reactive oxygen species, but also lead to alteration of the host antioxidant defense mechanisms. Such events may be, at least in part, responsible for the pathology and progression of fibrosis associated with schistosomal hepatitis. This study was designed to fulfill two aims; assessment of protective effect of the antioxidant Coenzyme-Q10 [Co-Q10] against the state of S. mansoni-induced oxidative stress in the liver, and evaluation of the potential role of Co-Q10 as an adjuvant to praziquantel [PZQ]. S. mansoni infected mice were divided into four main groups; group I control non-treated group. Group II received Co-Q10 after infection and was sacrificed 8 and 12 weeks post infection. Croup III treated by single oral dose of PZQ 8 weeks post infection. Group IV treated by single oral dose of PZQ 8 weeks post infection then was given Co-Q10 for four weeks. The oxidative stress and overall liver function were improved under Co-Q10 therapy as evidenced by significant reduction in oxidative stress markers, and preservation of antioxidant factors. Liver fibrosis was also reduced with a positive impact on liver function. Moreover, addition of Co-Q10 to PZQ therapy caused; significant reduction of liver egg load, significant improvement of the redox status, and lastly decreased liver fibrosis. From this study we concluded that Co-Q10 1] ameliorated the oxidative stress status, 2] reduced the degree of liver fibrosis, and 3] enhanced the efficacy of classical therapy in experimental S. mansoni-induced hepatitis