Propionic acid derivatives and the functions of the liver and the kidney in albino rats

ABSTRACT

A comparative study on the effects of two propionic acid derivatives on liver and kidney functions and their withdrawal was performed on sixty adult male albino rats that were divided into two equal pirprofen and ketoprofen groups. Each group, 30 rats, was equally subdivided into a control, a drug treated [receiving either pirprofen [30 rrig/kg] or ketoprofen [12 mg/ kg] for three weeks] and a withdrawal subgroups [after one month of either drug cessation] .With the use of pirprofen, a highly significant increase in aspartate aminotransferase [ASAT], alanine amino-tansferase [ALAT], alkaline phosphatase, creatinine and blood urea and a highly significant decrease in total proteins and prothrombin activity were observed. After one month drug withdrawal, no significant changes in ASAT, ALAT, total proteins, and blood urea were observed but a significant decrease in prothrombin activity and an increase in alkaline phosphatase was still reported. Upon ketoprofen administration, a highly significant decrease in total proteins and prothrombin activity and a highly significant increase in all the rest of hepatic and renal parameters was recorded. While upon one month drug withdrawal, these significant changes were still observed except for blood urea that was insignificantly changed in comparison to the control. From all the above findings one could conclude that, though pirprofen appears safer than ketoprofen, yet both should not be used habhazardly. Also, upon their therapeutic administration, routine liver and kidney functions should be accessed to guarantee for safety usage