CD10 immunoreactivity in cutaneous squamous and basal cell carcinoma

ABSTRACT

The aim of this study was to compare CD10 expression in tumoral and stromal cells of cutaneous squamous cell carcinoma [SCC] and basal cell carcinoma [BCC] in order to differentiate SCC from BCC in problematic cases. Twenty six SCC and 30 BCC cases were retrieved randomly from Al-zahra hospital pathology archive and CD10 expression was determined in tumoral and stromal cells [fibroblasts around tumoral nests] of each case based on immunohistochemical method. 25 of 26 SCC samples [96.2%] failed to stain with CD10 in tumoral cells whereas CD10 expression of stromal cells was identified in all SCC cases [100%]. In contrast, 26 of 30 BCC cases [86.7%] were positive in tumoral cells and only 5 of 30 BCC samples [17.7%] were positive in stromal cells. Accordingly, the staining pattern of tumoral and stromal cells in BCC and SCC was statistically different [p < 0.001]. These findings support CD10 expression as a differential marker for BCC and SCC. CD10 staining pattern is mostly tumoral in BCC and stromal for SCC