Clonidine premedication: a useful adjunct in producing induced hypotension with total intravenous anesthesia for middle ear microsurgery

ABSTRACT

Thirty adult patients were studied to evaluate the role of oral clonidine premedication on the dose requirement of intraoperative labetalol to produce induced hypotension during total intravenous anaesthesia [propofol I fentanyl] for middle ear microsurgery. Also studied was surgeon's satisfaction and quality of recovery. Patients with oral clonidine [4 micro g/kg] premedication [Group-II, n-15] demonstrated insignificant [p>0.05] pressor response to laryngoscopy intubation. Group II patients needed a mean of only 4.2 mg labetalol to keep the intraoperative mean arterial pressure between 60-75 mmHg as compared to 25.0 mg required in the unpremedicated group [Group I, n-15]. Surgeon's satisfaction with the operative field was similar in both the groups. However recovery time was significantly prolonged in patients receiving oral clonidine premedication