Granulocytic sarcoma in bone preceding diagnosis of acute leukemia a report of two cases

ABSTRACT

Granulocytic sarcomas may develop during the course of, or as a presenting sign of, myelogenous leukemia. Rarely, however, an extramedullary neoplasm composed of poorly differentiated granulocytic cells occurs in patients without peripheral blood or bone marrow evidence of leukemia. We encountered two cases of granulocytic sarcoma [chloroma] of bone with negative blood and bone marrow finding. Before and after biopsy taking we were confused about the diagnosis and we had to review the literature. The aim of this work is to put this lesion in focus, so that orthopaedic surgeons may not be confused on facing such lesion