study of the coagulopathy of nephrotic syndrome and its relation to quantitative estimation of protein C

ABSTRACT

Ten children were having nephrotic syndrome during relapse, ten were during remission and the other twenty were normal children, age and sex matched as control. After good history taking and thorough clinical examination, complete urine examination was done, serum albumin, serum cholesterol, ESR, partial thrombo plastin time [PTT], and protein C antigen level in plasma. None of the children had any evidence of thrombo-embolic manifestations on clinical grounds. There was a significant rise of PC% in nephrotic children during relapse than in the remission group and the control. No significant difference was present between the nephrotic group in remission and the control group. A negative correlation was shown between serum albumin and protein C level, while there was a positive correlation between serum cholesterol and protein C level.As regards PTT there was a significant decrease in group A as compared to both group B and C although group A cases were showing no thromboembolic manifestation, yet still they have got the tendency to thrombosis