Glomerulosclerosis; lipids and lipoproteins, a risk factor

ABSTRACT

Objective is to determine the changes in lipids and lipoproteins in patients with glomerulosclerosis and healthy controls. Department of Biochemistry Frontier Medical College, Abbottabad with the collaboration of Nephrology Unit, Ayoub Medical Complex, Abbottabad. April, 2006 February 2007. Study includes 50 subjects out of which 25 adult patients [18 males, 7 females; age range 20 50 years] with glomerulosclerosis were selected from Nephrology Unit of Ayoub Medical Complex, Abbottabad. Apparently, 25 clinically healthy volunteers of similar age, sex, body mass index [BMI], and socio economic status as that of patients were selected from various areas of Abbottabad as controls Serum triacylglycerols serum total cholesterol, and HDL cholesterol levels were measured by kit method LDL cholesterol was calculated according to the Friedewald formula[17]. Serum VLDL-cholesterol as calculated according to the formula proposed by Wilson cited by Delongi[18]. The results were expressed as mean +/- standard error of mean Statistical analysis was done using student 's test. Distribution of 25 patients and 25 controls according to age is made. Male subjects with glomerulosclerosis were greater in number than female with male to female ratio of 1.851 Comparison of serum TGs, TC, HDL-c, LDL-c, VLDL-c, and HDL-c, LDL-c ratio. The mean values of TAGs, TC, HDL-c, LDL-c, VLDL-c, and ratio of HDL-c, vs. LDL-c of patients were observed significantly high [P<0.001], when compared to controls. In addition significant low values [P<0.001] of HDL-c in patients were also observed when compared to healthy controls. It is concluded that the results of this study provide evidence for raised lipids and lipoproteins levels, which is invariable feature of nephritic syndrome with glomerulosclerosis. It is suggested that the patients with nephritic glomerulosclerosis should be assessed and managed to avoid potential of accelerating the development of coronary artery disease and increasing risk of renal failure. Hopefully earlier intervention might decrease higher morbidity and mortality