[Clinical and therapeutic results of a retrospective study about 62 cases of epithelial ovarian carcinomas]

ABSTRACT

To report retrospectively the therapeutic results and prognostic factors of epithelial ovarian carcinomas throughout a series of 62 patients treated between 1993 and 2002. Patients were treated with primary surgery classified as optimal [complete], sub-optimal or minimal. Adjuvant ciplatin based poly chemotherapy [6 cycles] was indicated in FIGO stage Ic or more. Patients with minimal surgery received 3 or 4 cycles of chemotherapy followed by an interval debulking surgery. Overall survival was calculated according to Kaplan-Meier and univariate analysis done by the Log-Rank test for the following factors age group, surgical excision, stage, histological type and presence or not of ascitis at diagnosis. Fifty five patients were operated. The excision was optimal, suboptimal and minimal in respectively 19,3%, 33.8% and 40.3% of the cases. Adjuvant or neoadjuvant chemotherapy was given to 50 patients [93,5%]. Interval debulking surgery was complete in 7 among 13patients. At the first evaluation, 14/58 patients were in complete response. The 3 and 5 years overall survival rates were respectively of 25% and 13%. Advanced stage was the only pejorative prognostic factor [P= 0.0002]. Incomplete surgery [minimal] and chemotherapy without taxanes based chemotherapy were associated with poor outcome in our patients. Our study confirmed the importance of disease stage as a prognostic factor