Effect of sodium nitroprusside on some liver functions and portal pressure in bilharzial patients

ABSTRACT

The effect of small dose of Na nitroprusside [0.1-0.2 mg/kg] on some liver function tests, mean arterial blood pressure, and acid base has been studied in 20 bilharzial patients. Liver function tests were mildly affected and all figures returned to control values within 48 hours. Portal pressure was markedly reduced out of proportion to the drop in arterial pressure. Acid base and blood gases were not affected. The use of Na nitroprusside for reduction of portal pressure in the preoperative period and during operations for patients with portal hypertension needs to be further investigated as regards the effects of larger doses on liver function and acid base