Effect of amitriptyline on blood glycose, insulin, lipids, thyroid function, electrolytes and some brain amino acids in rabbits

ABSTRACT

The intraperitoneal administration of amitriptyline [10 mg/kg body weight for 14 days] resulted in a significant decrease in blood glucose, significant increase in the blood insulin level, significant decrease in the levels of free fatty acids [FFA], triglycerides and total cholesterol. It also produced a significant decrease in both sodium and potassium levels and an increase in brain GABA level. However, T3, T4, TSH and brain L-glutamic acid showed no change. The probable significance of the findings is discussed