study of the metabolic aspects of leukaemias

ABSTRACT

This research was undertaken in order to find out the metabolic variations in three groups of leukemic patients in comparison with normal group. Several investigations were done to all patients and controls. Patients with acute leukemia showed significant decrease in serum glucose, zinc, sodium, potassium and serum calcium, while significant increase in serum uric acid, acid phosphatase, lactic acid dehydrogenase, copper and serum phosphorus. Patients with chronic myeloid leukemia showed significant decrease in serum glucose, significant increase in serum uric acid and lactic A. dehydrogenase, while normal results were obtained from the other parameters. Results of chronic lymphocytic leukemia were within normal. Hematological studies showed variable degrees of anemia, thrombocytopenia in acute and chronic lymphocytic cases, but normal platelet count were found in chronic myeloid leukemia. Wide ranges of peripheral blood leucocytosis were found in all patients, except two acute cases; their count were below normal. Bone marrow picture in acute cases showed an increase in the nucleated cells in total count, and predominance of blast cells in the differential count. Reticulum cells, promyelocytes, myelocytes and monocytes showed marked increase