effect of histamine receptor blockers [mepyramine maleate and cimetidine], on experimental acute portal hypertension

ABSTRACT

This work aimed to study the effect of H1 and H2-receptors blockers on the portal venous pressure separately and in combination. Experimental portal hypertension was done by clamping the portal vein of dogs, simulating what happens in schistosomal hepatic fibrosis. H1-receptor blocker [mepyramine maleate] was used in five dogs, H2-receptor blocker [cimetidine] was used in five dogs, and in other five dogs both H1 and H2-receptor blockers were used. It was found that the synergestic action of both H1 and H2-receptor blockers causes more lowering of the portal blood pressure than using any of them alone, which is helpful in bleeding esophageal varices