Indapamide-digoxin interaction

ABSTRACT

Thirty-two adult male rabbits [1-1.5 kg body weight] were used in this study. They were divided into four groups Indapamide group, digoxin group, combined group, and the control group. Determination of serum digoxin level by radioimmunoassay, serum sodium and potassium by flame photometer, serum calcium and magnesium by atomic absorption was done. A significant increase of serum digoxin level by indapamide was observed. Also, nifedipine had increased serum digoxin concentration