effect of antidepressants on gastric secretion and their possible protective effect on phenylbutazone induced ulcer in rats

ABSTRACT

The effect of amitriptyline and maprotiline [5 mg/kg body weight] on gastric secretory activity was studied in rats. Th2 volume of the gastric secretion, hydrochloric acid concentration and peptic activity were determined. The effect of the drugs on phenylbutazone induced ulcers was also studied. The results showed a significant reduction in hydrochloric acid concentration and peptic activity. Amitriptyline caused a significant reduction in the volume of the gastric secretion and imparted a protective effect on the gastric mucosa