Effect of verapamil on histamine and pentagastrin-stimulated gastric acid secretion in man

ABSTRACT

The effect of verapamil on the histamine and the pentagastrin-stimulated gastric acid secretion had been studied in normal volunteers. Histamine, pentagastrin, or verapamil increased the volume of gastric secretion and acidity when given separately. However, when histamine was followed by verapamil, the volume and acidity dropped, while pentagastrin followed by verapamil administration did not alter the volume nor the acidity. On the other hand, when histamine was proceeded by verapamil, a nonsignificant drop in volume and a significant drop in acidity could be traced, but pentagastrin proceeded by verapamil administration caused a nonsignificant rise in the studied parameters. The data suggested that calcium partly acts as a second messenger, together with cAMP, in the histamine-induced gastric acid secretion. While, the role of calcium in the gastrinergic pathway remains to be further elucidated