Some aspects of carbohydrate metabolism in patients of chronic renal failure

ABSTRACT

Carbohydrate metabolism was studied in 20 non diabetic patients with chronic renal failure and ten normal controls. The study showed a positive correlation between glucose intolerance was demonstrated in 70% of uremic patients, yet a high fasting serum insulin level was demonstrated in 55% of them. Also a high insulinogenic index was found in 40% of the patients indicating hyperinsulinism. It was suggested that the cause of glucose intolerance in chronic renal failure was probably due to a peripheral insulin antagonism