Study of the influence of ranitidine and phenylbutazone on oral iron absorption in rabbits

ABSTRACT

The present study aimed at evaluating the effect of prolonged oral administration [10 days] of ranitidine hydrochloride [10 mg/kg] and phenylbutazone [100 mg/kg] along and with ferrous sulfate [10 mg/kg], on the bioavailability of iron for intestinal absorption. Also, post absorption plasma iron tolerance curve was done to all groups. Fifty adult male rabbits were arranged into a control group, a ranitidine group and a phenylbutazone group. Ranitidine produced a significant decrease in plasma iron level when used alone [24.60%] as well as when given simultaneously with ferrous sulfate [12.82%], while phenylbutazone whether given alone or with ferrous sulfate produced a statistically insignificant rise plasma iron [6.32% and 12.90%, respectively]