Secretory IgA level in schistosomal colonic polyposis

ABSTRACT

This study was carried out on 20 patients with early intestinal schistosomiasis and 20 cases of schistosomal intestinal polyposis. A group of 10 healthy subjects was also included as control. This work aimed at evaluating colonic tissue secretory IgA levels for patients in both groups. Serum IgA level in schistosomal patients showed no significant difference compared with the control group. Also, no significant difference in secretory IgA could be obtained in the intestinal schistosomal patients compared with the control subjects. On the other hand, polyploid tissue contained higher levels of secretory IgA than normal mucosal tissue. The excess secretory IgA in polyploid tissue support the suggestion that it can mediate cellular immune response and share in the formation of antigen antibody complexes. Secretory IgA accordingly may play a role in the pathogenesis of schistosomal colonic polyposis