Effect of the converting enzyme inhibitor [Captopril] and its interaction with the calcium antagonist [Verapamil] on lipid metabolism

ABSTRACT

The effect of a converting enzyme inhibitor [captopril] and its interaction with a calcium antagonist [verapamil] on lipid metabolism was studied. A daily dose of captopril [1 mg/200 g body weight] for 3 weeks was given to 8 rats, another group of 8 rats was given the same daily dose of captopril together with a daily dose of verapamil [125 mug/200 g body weight] for 3 weeks. At the end of the 3 weeks investigation of the differences in lipid patterns was done. Captopril alone caused significant increase in total cholesterol and triglycerides, but in the group treated with captopril and verapamil a less significant increase was revealed in total cholesterol. There were also significant changes in the different concentrations of lipoprotein fractions in the two groups. The verapamil was found to modulate the effect of captopril