Study of serum and cerebrospinal fluid level of major and trace elements in chronic renal failure patients associated with nervous system manifestations [part I]

ABSTRACT

Studies were done on 31 CRF patients, 10 undialysed and 21 patients undergoing haemodialysis including 11 patients with nervous manifestations and the other 10 patients without nervous manifestations. 10 normal subjects were included as a control group. The level of sodium, potassium, magnesium, calcium and phosphorus were estimated in serum and CSF by Atomic Absorption Spectophotometry. There was significant increase in serum and CSF levels of sodium, potassium, magnesium and phosphorus and significant decrease in serum and CSF calcium in CRF patients as compared to control group. The haemodialysed patients showed a significant elevation of serum and CSF potassium, magnesium and phosphorus and insignificant change in serum and CSF sodium and calcium as compared to control group. There was insignificant change of serum and CSF levels of the studied elements in dialysed CRF patients with nervous manifestations as compared to patients without CNS manifestations as compared to patients without CNS manifestations