Study of serum and cerebrospinal fluid level of major and trace elements in chronic renal failure patients associated with nervous system manifestations [part II]

ABSTRACT

Studies were done on 31 CRF patients, 10 undialysed and 21 patients undergoing haemodialysis including 11 patients with nervous manifestation and the other 10 patient without nervous manifestations, 10 normal subjects were included as a control group. The level of zinc, copper, iron, lead, manganese and aluminium were estimated in serum and CSF by Atomic Absorption Spectrophotometry. There was significant increase in serum and CSF level of lead and aluminium, and insignificant change in serum and CSF copper in CRF patients as compared to control group. The haemodialysed patients showed significant elevation of serum and CSF copper, lead and aluminium, and significant decrease of serum and CSF zinc, iron and manganese as compared to control group. The haemodialysed patients with nervous manifestations showed a significant elevation serum and CSF aluminium and insignificant change of serum and CSF levels of other elements as compared to the patients without nervous manifestations