Effect of some antidiabetic drugs on lipid profile in type-II diabetes mellitus

ABSTRACT

Plasma lipids [cholesterol, triglycerides and total lipids] were studied in 40 patients with type II diabetes mellitus [NIDDM] before and after antidiabetic therapy. All patients were divided into 2 groups according to the type of antidiabetic therapy received Group A, 20 patients treated with glibenclamide and group B, 20 patients treated with insulin. A significant elevation of triglycerides was found in diabetic patients while cholesterol and total lipids showed insignificant elevation. Insulin appears to be more effective in lowering both triglycerides and cholesterol than glibenclamide, but the two drugs are effective as regards the total lipids. The better effect of insulin in lowering the blood lipids than glibenclamide may be attributed to a more better control of the diabetic state