Phenytoin toxicity

ABSTRACT

Of the currently treated epileptics with gr and mal and partial seizures referred to the neurology clinic and treated with phenytoin assisted by serum level monitoring, 20 patients with phenytoin toxicity have been studied. All showed a good compliance to medication, their kidney and liver functions were normal. One patient was suicidal. Five were found to suffer from organic brain disease with symptomatic epilepsy. Three were due to overdose and the other three developed the toxicity after commencement of antiepileptic polytherapy. The remaining 8 cases had the toxicity without any apparent reason. The manifestations and circumstances of toxicity were discussed