Renal function and repeated pregnancies

ABSTRACT

Albumin excretion in urine, albumin/clearance ratio and transferrin clearance were estimated in 22 normal pregnant women around 35 weeks gestation and at 6 weeks postpartum. Ten of them were of low parity mean, 12 were of high parity together with 20 normal married non pregnant females who were taken as control. The high parity group showed significant increase in the value of albumin excretion, albumin clearance, albumin/creatinine clearance ratio and tranferrin clearance at 35 weeks gestation and at 6 weeks postpartum when they were compared with the control group and also when they were compared with the low parity group. The group of low parity showed significant changes in the same parameters at 35 weeks gestation but the levels returned near the control levels at 6 weeks postpartum. These data suggest that multiple pregnancies have an adverse effect on the glomerular permeability and hence on kidney function