effects of topical prostaglandin E2 on the nasal blood vessels. A study on patients with allergic rhinitis

In the present work, the effects of topical prostaglandin E2 [dinoprostone] on the nasal blood vessels of patients with allergic rhinitis were studied. The outstanding changes were constriction of the arterioles and capillaries [to a lesser extent] and tight closure of the interendothelial junctions. These changes caused a diminution of nasal blood flow and edema formation, a reduction in the size of the turbinates and consequently an increase in nasal patency. However, the drug had no effect on the nasal venules. The present research revealed the possibility of using dinoprostone topically to relieve nasal obstruction in allergic patients