effect of food deprivation and refeeding on some renal functions and renal NA+-K+ ATPase activity in rats

ABSTRACT

Starvation is considered as a safety manner for reduction of weight in obesity taking into consideration the time factor and the ample supply of water. Results of the study proved that the metabolic responses and the changes in renal functions during starvation are reversible. This work was conducted on 28 rats divided into four groups, one control group and three fasted groups for three days with free access to water, two of the fasted groups were refed for two and five days. The body weight, the water intake and urinary output were decreased during starvation then normalized after refeeding. Significant decrease in creatinine clearance, urea excretion, blood bicarbonate and blood pH were observed during starvation, then returned to normal at the end of the fifth day of refeeding. Significant increase in serum sodium was reported while serum potassium was not affected; urinary excretion of sodium and potassium were decreased but all normalized on refeeding. Starvation did not alter serum chloride. Renal Na+ - K+ ATPase activity was significantly increased during starvation and normalized on refeeding