Schistosomiasis and colorectal carcinoma in Egypt

ABSTRACT

This work was carried out to throw light on the etiological importance of schistosomiasis in colorectal and the predictive value of some tumor markers TMs [CEA and CA19-9] in these tumors detection. It included 10 patients with sole colorectal carcinoma [group I], 10 others with colorectal cancer and schistosomiasis [group II], 15 with late intestinal schistosomiasis [group III] and 10 with early schistosomal colitis [group IV], in addition to 10 normal healthy controls [group V]. Results suggested that, it seems time to keep in mind the association between colorectal cancer and S. mansoni particularly in long standing infections. Sole determination of CEA and/or CA19-9 is not enough for diagnosis of colorectal carcinoma. Screening of high risk groups using these markers would require longer follow up along with histopathological study. Furthermore, it could be postulated that the primary role of these TMs in cancer colon and rectum might be assessment of complete tumor excision as well as postoperative surveillance of patients at risk of recurrence