Influence of natural wild honey on the cardiac muscle activity "an approach to mechanism of action". In vitro study

ABSTRACT

In this investigation, an in vitro study was performed to emphasize the mechanism of action of a natural wild honey on the heart function. The wild honey was obtained from the area of Saint Katherine Protectorate, Southern Sinai, Egypt. Isolated toad hearts were perfused with the wild honey [0.5 g/ml]. Electrocardiograms [ECGs] of the isolated toad hearts were recorded for 30 minutes. A chemical analysis of the wild honey was performed to clarify the complexity of the blend of components and to establish the relationship between the honey constituents and its mode of action. Significant bradycardia accompanied by negative dromotropism was obtained following the application of the wild honey. Neither atropine nor nicotine could abolish the previous noticed effects. A gradual and progressive increase in R-wave amplitude was also noticed, reflecting positive inotropism of the honey. The application of verapamil could abolish this effect. Substantial quantities of calcium, potassium, chlorine, sodium and magnesium were estimated in the wild honey