Patient profile and results of multimodality therapy in patients with colorectal carcinoma treated in tertiary referral hospital in Egypt

ABSTRACT

The objective of this work was to study the disease pattern in colorectal carcinoma patients, evaluate the results of the therapy adopted and to speculate the possible advances which can improve the results of treatment. A retrospective analysis of 97 patients with rectal adenocarcinoma treated at the Clinical Oncology Department and the Surgical Oncology Unit at Mansoura University Hospital in Egypt in the period from January 1998 to December 2003 was done. The patients' age, sex and presenting symptom were recorded. The tumor grade and clinical staging were collected, then the treatment plan and survival data were recorded. The mean age of the studied group was 42 [16-80] years, 54 were males and 43 were females. Seventy-two cases had curative surgery, abdominoperineal resection [APR] in 45 patients and low anterior rectal resection [LAR] in 25 patients. Eighty-seven patients received radiation therapy; of them, 66 cases received postoperative radiation therapy, 6 patients preoperative and 15 palliative irradiation. Eighty-three patients received chemotherapy, 5-Fu and leucovorin being the commonest regimen received. The local recurrence rate in this study was 8.4%. The 5-year disease free survival and overall survival were 54% and 56.5%, respectively