Monoclinical gammopathy: ten years' experience at King Faisal Specialist Hospital in Riyadh, Saudi Arabia

ABSTRACT

One hundred eleven cases of monoclonal gammopathy seen between 1979 and 1986 were reviewed. The mean age of the patients was 53 years, and the male to female ratio was 1.51. Of 111 cases, 66 [59.5%] had plasma cell dyscrasia, 22 [19.8%] had malignant lymphoma or carcinoma, eight [7.2%] had hematological disease, 12 [10.8%] had inflammatory conditions, and three [2.7%] had other miscellaneous associated conditions of undetermined orign. Of patients with plasma cell dyscrasia, 50 had multiple myeloma, five had light-chain disease, four had Waldenstrom's macroglobulinemia, and seven had solitary plasmacytoma. I[g]G accounts for 78.4% of monoclonal gammopathy followed by I[g]A [9.9%], I[g]M [7.2%], and free light chains [4.5%]. The patients with plasma cell dyscrasia ranged from 33 to 90 years with a mean age of 57 years, and male to female ratio of 21. In some conditions, the association of monoclonal gammopathy may be casually related, while in other conditions, the association may be coincidenta