Evolution of polyglandular autoimmune syndrome type I in a Saudi Arabian family
Annals of Saudi Medicine. 1988; 8 (6): 448-51
in English
| IMEMR
| ID: emr-121517
ABSTRACT
The clinical and laboratory findings are described in three male Saudi Arabia siblings, aged 28, 18, and 9 years and products of consanguineous marriage. In all three patients, serum calcium and parathyroid hormone were low, while serum phosphate was high. Patients 1 and 2 had low serum thyroxine, low serum cortisol, and elevated serum thyroid-stimulating hormone [TSH]. Patients 3 had normal serum thyroxine, cortisol, and TSH. Patients 1 had a high corticotrophin level and antibodies against pancreatic islet cells, and patients 1 and 2 both had significant titers of antibodies to thyroglobulin and microsomes. The findings described in this family are consistent with polyglandular autoimmune syndrome type I, in which patients 1 and 2 had primary hypoparathyroidism, hypothyroidism, and hypoadrenalism, developing in that order. So far, patients 3 has had only hypoparathyroidism
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Case Reports
/
Consanguinity
Language:
English
Journal:
Ann. Saudi Med.
Year:
1988
Similar
MEDLINE
...
LILACS
LIS