pathological effects of anticoagulant rodenticide difenacoum on white rats

ABSTRACT

Twenty-four albino rats were divided into two equal groups. The first group was treated with a single oral dose of 0.26 mg/kg b. wt. of difenacoum [1/5 LD50]. The rats of group two were used as control. Four rats of both treated and control were sacrificed at 1, 5 and 10 days after administration. Congested blood vessels, hemorrhagic areas, edema, lymphocytic aggregation and degenerated parenchymatous cells were the most common findings in the hearts, liver, kidneys, spleen, lungs, brain, testes, stomach and intestines of rats