overview of breast cancer

ABSTRACT

Breast cancer is a major health problem in many parts of the world. Its impact in Saudi Arabia will be more obvious when the national data is released from the National Cancer Registry [NCR] in the future. It is the most common cancer referred to the King Faisal Specialist Hospital and Research Centre [KFSH and RC]. This is a retrospective review of all female breast cancer cases treated at KFSH and RC over a 15-year period. Patients were divided into two groups at the time of their referral to KFSH and RC metastatic and nonmetastatic. We describe the demographic data, cancer-related information and the treatment offered to all patients. Comparisons were made between Saudi and non-Saudi, and the Saudis were examined in relation to their region of referral and observed to see if any changes occurred during the study period. As well, we tried to compare our results with experience elsewhere. A total of 1584 female breast cancer patients were treated at KFSH and RC between 1975 and 1991. Early breast cancer [Stages I, II] represented 36%, while 64% presented with advanced or metastatic disease [Stages III, IV]. The majority of patients were premenopausal [64%]. For patients with Stage I=III [1005], mastectomy was performed in 85% and lymph node dissection in 93%. Only 30% had no pathologic lymph node involvement and in 49% of the patients, lymph node dissection was adequate [>/= 10 nodes removed]. Estrogen and progesterone receptors were known in 30% of the patients. Sixty-two percent and 72% of patients referred from the central region and the northern region had Stages II and III, respectively. For the non-Saudis, we observed more premenopausal patients [76%] and fewer Stage III, At 15 years, the relapse-free survival in Stages I, II and III was 33%, and 18%, and the overall survival was 80%, 64% and 45%, respectively. Breast cancer in this population affects younger patients [premenopausal] and a higher proportion present with metastatic or locally advanced disease. Management strategies should incorporate conservative surgery when appropriate, and adequate lymph node dissection. This should be coupled with increasing public awareness and education and institution of screening programs. Overall survival is clearly linked to the stage of the disease