Immunolocalization of vascular and non vascular expression of VCAM-1 in hyperplastic, dysplastic oral mucosal lesions and squamous cell carcinoma

ABSTRACT

38 oral biopsy specimens of hyperplastic surface epithelial lesions [8 cases], epithelial dysplastic lesions [12 cases] and squamous cell carcinoma [SCC] [18 cases] as well as six biopsies of normal oral mucosa were processed for immunohistochemical staining with anti VCAM-1 to identify vascular and non vascular expression of VCAM-1 in the hyperplastic and dysplastic oral lesions as well as oral SCC compared to normal oral mucosa and to examine if it has an active role in the pathogenesis of these lesions that could point the way to the developing of new therapeutic stratigies. The results of this study suggested that VCAM-1 expression has essentially a direct relation with the density and distribution of chronic inflammatory cell infiltration. VCAM-1 is not related to the different grades of epithelial dysplasia and tumor cell differentiation. It cann't be also used as an indicator of tumor angiogenesis