[Prooxidant- antioxidant balance in CAD patients]

ABSTRACT

The balance between ROS generation and antioxidant activity is critical to the pathogenesis of oxidative stress related disorders. In this study the prooxidant - antioxidant balance and its correlation with lipid profile and uric acid was determined to evaluate the PAB as a prognostic factor for CAD. Seventy - two patients and sixty eight healthy volunteers were enrolled in this study. The values of PAB were determined by using standard solutions and ELISA method. Triglyceride, total cholesterol, LDL- cholesterol, HDL - cholesterol and uric acid were measured by enzymatic method. The PAB values of CAD patients and control group were 70.01 +/- 3.36 [HK unit] and 66.40 +/- 2.84 [HK unit] respectively. There was no significant difference between PAB values among the two groups [P= 0.41]. There was no significant difference between uric acid levels among the two groups [P= 0.46]. There was a significant correlation between the uric acid values among patients and healthy volunteers and PAB values [P <0.01]. There was a significant correlation between the TG, values among patients and healthy volunteers and PAB values [P<0.05]. This study showed oxidative stress could be used as a significant risk predictor in the coronary artery disease patient