Prevention of propofol injection pain with small-dose ketamine
Middle East Journal of Anesthesiology. 2009; 20 (3): 401-404
in English
| IMEMR
| ID: emr-123065
ABSTRACT
Propofol is a popular IV anesthetic induction drug that causes pain when given IV, the incidence of which is between 28%-90%. We plan to determine the optimal dose of ketamine in the prevention of propofol injection pain and compare it with lidocaine, the commonly proposed pre-treatment. In a double-blind randomized study 500 Patients [ASA I,II] scheduled for elective strabismus surgery under general anesthesia were randomly allocated into five groups. After obtaining the informed consent., patients received normal saline [Group NS], lidocaine 1mg.kg[-1] [Group L], and different doses of ketamine 50-75-100 micro g.kg[-1] [Group K50-K75-K100 respectively], immediately before the injection of 2.5 mg.kg[-1] propofol. Each patient's pain scores were measured at five seconds intervals by a blinded anesthesiologist. Statistical analysis were made by SPSS vs 11.5. The incidence and intensity of pain in all study groups were significantly lower than placebo group [Group NS] [P<0.005]. Patients in the K100 Group had significantly lower incidence of pain and lower pain scores compared with the K50 and L Groups [P<0.001]. There were no significant differences in hemodynamic parameters between groups. Administration of ketamine 100 micro g.kg[-1] immediately before propofol injection is a safe and effective method in preventing propofol injection pain
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pain
/
Placebos
/
Propofol
/
Strabismus
/
Double-Blind Method
/
Prospective Studies
/
Anesthesia, General
/
Ketamine
/
Anesthesia, Intravenous
/
Lidocaine
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Middle East J. Anesthesiol.
Year:
2009
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