Immunosuppressive effects of rifampicin on a tuberculosis patient after renal transplant
Pakistan Journal of Medical Sciences. 2011; 27 (3): 720-722
in English
| IMEMR
| ID: emr-123994
ABSTRACT
Rifampicin is a semisynthetic derivative of rifamycin B and inhibits the growth of a variety of bacteria. Rifampicin causes an increase in corticosteroid clearance, and a decrease in the blood concentrations of calcineurin inhibitors by inducing Cytochrome P[450] 3A4 in the liver. It is generally acknowledged that a substantial increase in the dosage of calcineurin inhibitors is required to achieve the efficacious target concentrations and avoid graft rejection. We report a case of patient who received a living-related donor renal transplant with stable renal function during the rifampicin based anti-tuberculosis treatment, even the blood concentration of tacrolimus [FK506] decreased. Interestingly, acute rejection was observed at the end of anti-tuberculosis treatment, even the blood concentration of FK506 was reduced to target level
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rifampin
/
Tuberculosis
/
Immunosuppression Therapy
/
Kidney Transplantation
/
Calcineurin
/
Graft Rejection
/
Immunosuppressive Agents
/
Antitubercular Agents
Type of study:
Case report
Limits:
Female
/
Humans
Language:
English
Journal:
Pak. J. Med. Sci.
Year:
2011
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