liver in chronic renal failure: a histochemical study

ABSTRACT

The nature of the biochemical disturbances that causes the alteration in metabolism in chronic renal failure with the consequent multi- system affection constitutes a major problem. The present work examined the enzymatic changes of hepatocytes in uraemia. Twenty patients and ten controls were studied. Liver biopsies were taken and cryostat sections were subjected to a histochemical study. It was found that the activity of succinic dehydrogenase and alkaline phosphatase were decreased, while an increase in the activity of alpha- esterase hepatic effects was not detected. Nutritional depletion, electrolyte abnormalities and increased lipid peroxidation are of doubtful roles, while altered cytoplasmic composition, fluidity and regulation could be suggested