High molecular weight kininogen [MHWK] in patients with schistosomal hepatic fibrosis

ABSTRACT

Plasma level of high molecular weight kininogen [HMWK] was measured in 11 patients with schistosomal hepatic fibrosis and 12 healthy control subjects using clotting assay. Prothrombin time [PT], partial thromboplastin time [PTT], alanine transaminase [ALT], serum aspartate transaminase [AST], and estimation of total serum proteins and serum albumin were also performed. HMWK was decreased in patients with schistosomal hepatic fibrosis. No significant correlation was found between HMWK, PT, PTT and other liver function tests. The decrease in HMWK suggest impairment of the hepatic synthetic function in schistosomal hepatic fibrosis