Diuretic therapy in hypertension, and its effects on lipoprotein pattern

ABSTRACT

In this work, 19 hypertensive patients were thoroughly examined, and divided into 3 groups according to the diuretics used. The first group comprised 5 diabetic patients given spironolactone, the second contained 6 diabetics given ethacrynic acid, but the third group consisted of 8 non diabetic patients given frusemide. Investigations were done for every case e.g. urine and stool analyses, X-ray chest, E.C.G., blood sugarlevel and serum creatinine, in addition after treatment. In group I, we found insignificant increase in cholesterol triglycerides and total lipids but in group II, inspite of insignificant increase in triglycerides and total lipids, the cholesterol was decreased insignificantly. In the third group there were significant increase in triglycerides and ongly insignificant increase in both cholesterol and total lipids